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Cold Spring Harb Perspect Med. 2014 Aug 1;4(8). pii: a015248. doi: 10.1101/cshperspect.a015248.

p53/p63/p73 in the epidermis in health and disease.

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Centre for Skin Sciences, University of Bradford, Richmond Road, Bradford BD7 1DP, United Kingdom Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118.
Department of Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, Metastasis Research Center, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030.


Although p53 has long been known as the "guardian of the genome" with a role in tumor suppression in many tissues, the discovery of two p53 ancestral genes, p63 and p73, more than a decade ago has triggered a considerable amount of research into the role of these genes in skin development and diseases. In this review, we primarily focus on mechanisms of action of p53 and p63, which are the best-studied p53 family members in the skin. The existence of multiple isoforms and their roles as transcriptional activators and repressors are key to their function in multiple biological processes including the control of skin morphogenesis, regeneration, tumorigenesis, and response to chemotherapy. Last, we provide directions for further research on this family of genes in skin biology and pathology.

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