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Cold Spring Harb Perspect Biol. 2014 Aug 1;6(8). pii: a018747. doi: 10.1101/cshperspect.a018747.

Structural and functional coordination of DNA and histone methylation.

Author information

1
Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322.

Abstract

One of the most fundamental questions in the control of gene expression in mammals is how epigenetic methylation patterns of DNA and histones are established, erased, and recognized. This central process in controlling gene expression includes coordinated covalent modifications of DNA and its associated histones. This article focuses on structural aspects of enzymatic activities of histone (arginine and lysine) methylation and demethylation and functional links between the methylation status of the DNA and histones. An interconnected network of methyltransferases, demethylases, and accessory proteins is responsible for changing or maintaining the modification status of specific regions of chromatin.

PMID:
25085914
PMCID:
PMC4107986
DOI:
10.1101/cshperspect.a018747
[Indexed for MEDLINE]
Free PMC Article

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