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Appl Environ Microbiol. 2014 Oct;80(20):6290-302. doi: 10.1128/AEM.02308-14. Epub 2014 Aug 1.

Genomic encyclopedia of type strains of the genus Bifidobacterium.

Author information

1
Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Italy.
2
Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Cork, Ireland.
3
Departamento de Microbiologia y Bioquimica de Productos Lacteos, IPLA_CSIC, Villaviciosa, Asturias, Spain.
4
Department of Food Science, University of Liege, Belgium.
5
Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, North Carolina, USA.
6
Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Italy marco.ventura@unipr.it.

Abstract

Bifidobacteria represent one of the dominant microbial groups that are present in the gut of various animals, being particularly prevalent during the suckling stage of life of humans and other mammals. However, the overall genome structure of this group of microorganisms remains largely unexplored. Here, we sequenced the genomes of 42 representative (sub)species across the Bifidobacterium genus and used this information to explore the overall genetic picture of this bacterial group. Furthermore, the genomic data described here were used to reconstruct the evolutionary development of the Bifidobacterium genus. This reconstruction suggests that its evolution was substantially influenced by genetic adaptations to obtain access to glycans, thereby representing a common and potent evolutionary force in shaping bifidobacterial genomes.

PMID:
25085493
PMCID:
PMC4178644
DOI:
10.1128/AEM.02308-14
[Indexed for MEDLINE]
Free PMC Article
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