Format

Send to

Choose Destination
Eur J Public Health. 2015 Jun;25(3):431-3. doi: 10.1093/eurpub/cku126. Epub 2014 Jul 31.

Folate concentrations during pregnancy and autistic traits in the offspring. The Generation R Study.

Author information

1
1 The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands 2 Department of Child and Adolescent Psychiatry/psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands.
2
1 The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands 3 Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands 4 Department of Paediatrics, Erasmus Medical Centre, Rotterdam, The Netherlands.
3
2 Department of Child and Adolescent Psychiatry/psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands 3 Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands 5 Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands.
4
2 Department of Child and Adolescent Psychiatry/psychology, Erasmus MC-Sophia, Rotterdam, The Netherlands 5 Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands s.roza@erasmusmc.nl.

Abstract

In a population-based study, we examined the associations of maternal plasma folate concentrations at 13 weeks of gestation and prenatal folic acid supplement use with autistic traits in the offspring at the age of six years. Parent-reported autistic traits were assessed using the Social Responsiveness Scale short form. Maternal folate was not associated with autistic traits in the offspring. In contrast, prenatal folic acid use was associated with less child autistic traits. Future research should focus on the timing of the potential effect of prenatal folate on the development of autistic traits in combination with clinical diagnosis of autism in the offspring.

PMID:
25085472
DOI:
10.1093/eurpub/cku126
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center