Format

Send to

Choose Destination
Med Mycol. 2014 Oct;52(7):667-73. doi: 10.1093/mmy/myu030. Epub 2014 Jul 31.

Molecular identity and prevalence of Cryptococcus spp. nasal carriage in asymptomatic feral cats in Italy.

Author information

1
Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università 10, 35020, Legnaro, Padua, Italy Department of Veterinary Medicine, University of Bari, Str. prov.le per Casamassima Km, 3, 70010, Valenzano, Bari, Italy pdanesi@izsvenezie.it.
2
Veterinary regional district service ULSS 20, Local Public Health and Social Authority of Veneto Region, Via di Campo Marzo 20, 37133, Verona, Italy.
3
Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università 10, 35020, Legnaro, Padua, Italy.
4
Department of Veterinary Medicine, University of Bari, Str. prov.le per Casamassima Km, 3, 70010, Valenzano, Bari, Italy.

Abstract

Cryptococcosis is a life-threatening fungal disease that infects humans and animals worldwide. Inhalation of fungal particles from an environmental source can cause primary infection of the respiratory system. As animals can be considered a sentinel for human diseases, the aim of this study was to determine the prevalence and molecular identity of Cryptococcus spp. in the nasal cavity of feral cats. Cats from 162 urban and rural feral cat colonies were sampled over 3 years. Of 766 cats from which nasal swabs were obtained, Cryptococcus spp. were recovered from 95 (12.6%), including 37 C. magnus (4.8%), 16 C. albidus (2.0%), 15 C. carnescens (1.9%), 12 C. neoformans (1.6%), as well as C. oeirensis (n = 3), C. victoriae (n = 3), C. albidosimilis (n = 2), Filobasidium globisporum (n = 2), C. adeliensis (n = 1), C. flavescens (n = 1), C. dimnae (n = 1), C. saitoi (n = 1), and C. wieringae (n = 1) with prevalence <1%. Thirteen Cryptococcus species were identified by polymerase chain reaction and sequencing of internal transcribed spacer amplicons. Statistical analysis did not identify any predisposing factors that contributed to nasal colonization (eg, sex, age, season, or habitat). Results suggest that asymptomatic feral cats may carry C. neoformans and other Cryptococcus species in their sinonasal cavity. Genotyping of the specific cryptococcal isolates provides a better understanding of the epidemiology of these yeasts.

KEYWORDS:

Cryptococcus neoformans; asymptomatic cat; nasal cavities; yeasts

PMID:
25082953
DOI:
10.1093/mmy/myu030
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center