Ovarian epithelium regeneration by Lgr5(+) cells

Nat Cell Biol. 2014 Aug;16(8):743-4. doi: 10.1038/ncb3020.

Abstract

Lgr5, a marker of stem cells in many organs, is found expressed in cells scattered through the ovarian epithelium that expand to repair and regenerate the damaged ovarian surface after each ovulation. Lgr5-positive stem cells in the ovary and the fimbria of the oviduct may be critical cells of origin for ovarian cancer.

Publication types

  • Comment

MeSH terms

  • Animals
  • Fallopian Tubes / cytology*
  • Fallopian Tubes / metabolism*
  • Female
  • Humans
  • Ovary / cytology*
  • Ovary / metabolism*
  • Receptors, G-Protein-Coupled / genetics*

Substances

  • Lgr5 protein, mouse
  • Receptors, G-Protein-Coupled