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Eur J Cardiothorac Surg. 2015 May;47(5):778-87. doi: 10.1093/ejcts/ezu279. Epub 2014 Jul 31.

Ventricular structure-function relations in health and disease: part II. Clinical considerations.

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Department of Cardiothoracic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Department of Pediatrics and Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
Division of Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.


Normal cardiac function of the left and right ventricles, together with the septum, is related to form/function interactions within the helical ventricular myocardial band. This knowledge is a prerequisite to understanding form/function interactions in diseases and for planning new treatments. Topics discussed include congestive heart failure in dilated hearts of ischaemic, valvar or nonischaemic origin as well as diastolic dysfunction. Similar thinking underlies novel treatments for dyssynchrony in pacing, together with focusing upon varying global left or right ventricular anatomy to correct mitral and tricuspid insufficiency caused by tethering of the leaflets. The septum is the lion of the right ventricle and insight is provided into offsetting septal damage during cardiac surgery, rebuilding its anatomical structure in post-tetralogy pulmonary insufficiency, as well as rectifying its dysfunction by decompression in patients with a left ventricular assist device.


Dominant forces; Helical ventricular myocardial band; Timing hiatus; Torsion; Uncoiling

[Indexed for MEDLINE]

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