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J Asian Nat Prod Res. 2014 Oct;16(10):1029-34. doi: 10.1080/10286020.2014.933812. Epub 2014 Aug 1.

Talaflavuterpenoid A, a new nardosinane-type sesquiterpene from Talaromyces flavus.

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a Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou 510632 , China.


Talaflavuterpenoid A (1), a new nardosinane-type sesquiterpene, was isolated from the wetland soil-derived fungus Talaromyces flavus BYD07-13, and its structure was elucidated on the basis of HR-MS, NMR, and X-ray diffraction analysis. The absolute configuration of 1 was established by comparing the experimental electronic circular dichroism (ECD) spectrum with the calculated ECD spectra. Its cytotoxic effects on five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), and antimicrobial activity against Escherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus niger were evaluated. This is the first report of the presence of nardosinane-type sesquiterpene in Talaromyces sp.


Talaromyces flavus; biological activities; nardosinane-type sesquiterpene; structure elucidation; wetland soil-derived fungus

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