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Biosci Biotechnol Biochem. 2014;78(11):1939-42. doi: 10.1080/09168451.2014.943647. Epub 2014 Aug 1.

The importance of 1,2-dithiolane structure in α-lipoic acid for the downregulation of cell surface β1-integrin expression of human bladder cancer cells.

Author information

1
a Faculty of Agriculture, Department of Biochemistry and Applied Biosciences , University of Miyazaki , Miyazaki , Japan.

Abstract

Here, we show that cell surface β1-integrin expression, cell adhesion to fibronectin, migration, and invasion were all significantly inhibited by α-lipoic acid. These effects were not observed when cells were treated with dihydrolipoic acid or caprylic acid. These data reveal that the 1,2-dithiolane structure plays an important role in the action of α-lipoic acid.

KEYWORDS:

bladder cancer cells; invasion; migration; α-lipoic acid; β1-integrin

PMID:
25081893
DOI:
10.1080/09168451.2014.943647
[Indexed for MEDLINE]

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