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Arch Gerontol Geriatr. 2014 Nov-Dec;59(3):665-9. doi: 10.1016/j.archger.2014.07.002. Epub 2014 Jul 10.

Oxidative stress participates in age-related changes in rat lumbar intervertebral discs.

Author information

1
Department of Orthopedics, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
2
Department of Orthopedics, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: luhuading@gmail.com.
3
Department of Plastic Surgery, Guangzhou First Municipal People's Hospital, Guangzhou, China.

Abstract

Aging is a major factor associated with lumber intervertebral disc degeneration, and oxidative stress is known to play an essential role in the pathogenesis of many age-related diseases. In this study, we investigated oxidative stress in intervertebral discs of Wistar rats in three different age groups: youth, adult, and geriatric. Age-related intervertebral disc changes were examined by histological analysis. In addition, oxidative stress was evaluated by assessing nitric oxide (NO), superoxide dismutase (SOD), malondialdehyde (MDA), and advanced oxidation protein products (AOPPs). Intervertebral disc, but not serum, NO concentrations significantly differed between the three groups. Serum and intervertebral disc SOD activity gradually decreased with age. Furthermore, both serum and intervertebral disc MDA and AOPP levels gradually increased with age. Our studies suggest that oxidative stress is associated with age-related intervertebral disc changes.

KEYWORDS:

Aging; Intervertebral disc; Malondialdehyde; Nitrogen monoxide; Oxidative stress; Superoxide dismutase

PMID:
25081833
DOI:
10.1016/j.archger.2014.07.002
[Indexed for MEDLINE]

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