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Proc Natl Acad Sci U S A. 1989 Oct;86(19):7520-1.

Fruit flies with additional expression of the elongation factor EF-1 alpha live longer.

Author information

1
Biozentrum, University of Basel, Switzerland.

Abstract

In Drosophila melanogaster, the decrease in protein synthesis that accompanies aging is preceded by a decrease in elongation factor EF-1 alpha protein and mRNA. Here we show that Drosophila transformed with a P-element vector containing an EF-1 alpha gene under control of hsp70 regulatory sequences have a longer life-span than control flies.

PMID:
2508089
PMCID:
PMC298096
DOI:
10.1073/pnas.86.19.7520
[Indexed for MEDLINE]
Free PMC Article

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