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Cell Mol Life Sci. 2014 Nov;71(22):4403-20. doi: 10.1007/s00018-014-1695-z. Epub 2014 Aug 1.

Common and unique features of viral RNA-dependent polymerases.

Author information

1
Molecular Virology Laboratory, Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands, aartjan.tevelthuis@path.ox.ac.uk.

Abstract

Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average, these pathogens share little sequence similarity and use different replication and transcription strategies. Nevertheless, the members of nearly all RNA virus families depend on the activity of a virally encoded RNA-dependent polymerase for the condensation of nucleotide triphosphates. This review provides an overview of our current understanding of the viral RNA-dependent polymerase structure and the biochemistry and biophysics that is involved in replicating and transcribing the genetic material of RNA viruses.

PMID:
25080879
PMCID:
PMC4207942
DOI:
10.1007/s00018-014-1695-z
[Indexed for MEDLINE]
Free PMC Article

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