[Chlamydia trachomatis proteasome protein as one of the significant pathogenicity factors of exciter]

Mol Gen Mikrobiol Virusol. 2014:(2):3-8.
[Article in Russian]

Abstract

Sex-related infections are a global problem. Such infections may lead to acute or chronic diseases. Chlamydia trachomatis is a dangerous and widespread pathogenicity factor that is not sensitive to conventional drugs and has no obvious symptoms. Protein CPAF is leading factor of pathogenesis. This protein inhibits the signaling pathways of host cell and supports long survival of the pathogen in the host cell. The goal of this work was to review general properties of the proteasome Chlamydia protein CPAF, its functions, and role in pathology. The role of protein CPAF in the anti-chlamydia immune reaction is discussed. The prospects of the development of promising anti-chlamydia vaccine, as well as new effective anti-chlamydia drugs are also discussed.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / immunology
  • Bacterial Proteins / metabolism*
  • Bacterial Vaccines / genetics
  • Bacterial Vaccines / immunology
  • Bacterial Vaccines / therapeutic use
  • Chlamydia Infections / genetics
  • Chlamydia Infections / immunology
  • Chlamydia Infections / metabolism
  • Chlamydia Infections / prevention & control
  • Chlamydia trachomatis / genetics
  • Chlamydia trachomatis / immunology
  • Chlamydia trachomatis / metabolism
  • Chlamydia trachomatis / pathogenicity*
  • Endopeptidases / genetics
  • Endopeptidases / immunology
  • Endopeptidases / metabolism*
  • Humans
  • Microbial Viability / genetics
  • Microbial Viability / immunology
  • Proteasome Endopeptidase Complex / genetics
  • Proteasome Endopeptidase Complex / immunology
  • Proteasome Endopeptidase Complex / metabolism*
  • Signal Transduction / genetics
  • Signal Transduction / immunology

Substances

  • Bacterial Proteins
  • Bacterial Vaccines
  • Endopeptidases
  • Proteasome Endopeptidase Complex
  • CPA factor