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ACS Synth Biol. 2015 Apr 17;4(4):358-64. doi: 10.1021/sb500258b. Epub 2014 Aug 13.

Synthetic microbes as drug delivery systems.

Author information

1
Department of Bioengineering and Therapeutic Sciences and the California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California 94158, United States.

Abstract

Synthetic cell therapy is a field that has broad potential for future applications in human disease treatment. Next generation therapies will consist of engineered bacterial strains capable of diagnosing disease, producing and delivering therapeutics, and controlling their numbers to meet containment and safety concerns. A thorough understanding of the microbial ecology of the human body and the interaction of the microbes with the immune system will benefit the choice of an appropriate chassis that engrafts stably and interacts productively with the resident community in specific body niches.

KEYWORDS:

bacterial therapeutic; biosafety; delivery; diagnosis; human microbiome; signal integration

PMID:
25079685
PMCID:
PMC4410909
DOI:
10.1021/sb500258b
[Indexed for MEDLINE]
Free PMC Article

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