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Int J Mol Sci. 2014 Jul 30;15(8):13299-316. doi: 10.3390/ijms150813299.

Comparative evaluation of urinary PCA3 and TMPRSS2: ERG scores and serum PHI in predicting prostate cancer aggressiveness.

Author information

1
Medical Unit of Molecular Oncology and Transfer, Department of Biochemistry and Molecular Biology, University Hospital of Lyon Sud, Hospices Civils of Lyon, Chemin du Grand Revoyet, 69495 Pierre Bénite, France. lu.tallon@gmail.com.
2
Medical Unit of Molecular Oncology and Transfer, Department of Biochemistry and Molecular Biology, University Hospital of Lyon Sud, Hospices Civils of Lyon, Chemin du Grand Revoyet, 69495 Pierre Bénite, France. ldevillier@gmail.com.
3
Department of Medicine and Pharmacy, Faculty of Lyon 1 University, 8 Avenue Rockefeller, 69373 Lyon, France. denis.champetier@chu-lyon.fr.
4
Department of Medicine and Pharmacy, Faculty of Lyon 1 University, 8 Avenue Rockefeller, 69373 Lyon, France. marc.colombel@chu-lyon.fr.
5
Department of Medicine and Pharmacy, Faculty of Lyon 1 University, 8 Avenue Rockefeller, 69373 Lyon, France. marian.devonec@chu-lyon.fr.
6
Department of Urology, University Hospital of Lyon Sud, Hospices Civils of Lyon, Chemin du Grand Revoyet, 69495 Pierre Bénite, France. denis.champetier@chu-lyon.fr.
7
Department of Medicine and Pharmacy, Faculty of Lyon 1 University, 8 Avenue Rockefeller, 69373 Lyon, France. philippe.paparel@chu-lyon.fr.
8
Department of Medicine and Pharmacy, Faculty of Lyon 1 University, 8 Avenue Rockefeller, 69373 Lyon, France. myriam.decaussin-petrucci@chu-lyon.fr.
9
Department of Medicine and Pharmacy, Faculty of Lyon 1 University, 8 Avenue Rockefeller, 69373 Lyon, France. paul.perrin@chu-lyon.fr.
10
Medical Unit of Molecular Oncology and Transfer, Department of Biochemistry and Molecular Biology, University Hospital of Lyon Sud, Hospices Civils of Lyon, Chemin du Grand Revoyet, 69495 Pierre Bénite, France. virginie.vlaeminck-guillem@univ-lyon1.fr.

Abstract

It has been suggested that urinary PCA3 and TMPRSS2:ERG fusion tests and serum PHI correlate to cancer aggressiveness-related pathological criteria at prostatectomy. To evaluate and compare their ability in predicting prostate cancer aggressiveness, PHI and urinary PCA3 and TMPRSS2:ERG (T2) scores were assessed in 154 patients who underwent radical prostatectomy for biopsy-proven prostate cancer. Univariate and multivariate analyses using logistic regression and decision curve analyses were performed. All three markers were predictors of a tumor volume≥0.5 mL. Only PHI predicted Gleason score≥7. T2 score and PHI were both independent predictors of extracapsular extension(≥pT3), while multifocality was only predicted by PCA3 score. Moreover, when compared to a base model (age, digital rectal examination, serum PSA, and Gleason sum at biopsy), the addition of both PCA3 score and PHI to the base model induced a significant increase (+12%) when predicting tumor volume>0.5 mL. PHI and urinary PCA3 and T2 scores can be considered as complementary predictors of cancer aggressiveness at prostatectomy.

PMID:
25079439
PMCID:
PMC4159795
DOI:
10.3390/ijms150813299
[Indexed for MEDLINE]
Free PMC Article

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