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Curr Opin Immunol. 2014 Oct;30:63-71. doi: 10.1016/j.coi.2014.07.001. Epub 2014 Jul 31.

Genetics of gene expression in immunity to infection.

Author information

1
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. Electronic address: bfairfax@well.ox.ac.uk.
2
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK. Electronic address: julian@well.ox.ac.uk.

Abstract

Mapping gene expression as a quantitative trait (eQTL mapping) can reveal local and distant associations with functionally important genetic variation informative for disease. Recent studies are reviewed which have demonstrated that this approach is particularly informative when applied to diverse immune cell populations and situations relevant to infection and immunity. Context-specific eQTL have now been characterised following endotoxin activation, induction with interferons, mycobacteria, and influenza, together with genetic determinants of response to vaccination. The application of genetical genomic approaches offers new opportunities to advance our understanding of gene-environment interactions and fundamental processes in innate and adaptive immunity.

PMID:
25078545
PMCID:
PMC4426291
DOI:
10.1016/j.coi.2014.07.001
[Indexed for MEDLINE]
Free PMC Article
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