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Org Biomol Chem. 2014 Sep 21;12(35):6816-9. doi: 10.1039/c4ob01362j.

L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials.

Author information

1
Department of Chemistry, Brandeis University, 415 South St. MS015, Waltham, Massachusetts 02454, USA. bxu@brandeis.edu.

Abstract

An l-rhamnose-based hydrogelator self-assembles to form nanofibrils, which, in contrast to the properties of monomeric l-rhamnose, suppress the antibody response of mice to phycoerythrin (PE), a fluorescent protein antigen. As the first example of the supramolecular assemblies of a saccharide to suppress immunity, this work illustrates a new approach of immunomodulation.

PMID:
25078446
PMCID:
PMC4160809
DOI:
10.1039/c4ob01362j
[Indexed for MEDLINE]
Free PMC Article

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