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J Educ Health Promot. 2014 Jun 23;3:63. doi: 10.4103/2277-9531.134776. eCollection 2014.

Evaluation of preventive effects of colostrum against neonatal conjunctivitis: A randomized clinical trial.

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Departments of Pediatrics, Child Growth and Development Research Center, and Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.



Neonatal conjunctivitis leads to several ocular consequences in the affected neonates such as blindness. Currently available therapeutic options include NaNO3, Gentamicin, Neomycin and so on, in which each of them has their own limitations. Regarding the immunologic content of colostrum and its safety and easy accessibility, we aimed to evaluate its preventive effects against neonatal conjunctivitis.


In this clinical trial, conducted from November 2011 to July 2012, 300 preterm neonates, with culture negative eye swab, were enrolled and randomly assigned into three groups. The intervention group received two drops of colostrum. Control group received no treatment and other neonates were treated with topical Erythromycin ointment (0.5%). All neonates were followed for occurrence of clinical conjunctivitis for 28 days. Data analysis were performed by Chi-square test.


Our data demonstrate the beneficial preventive effects of Colostrum against neonatal conjunctivitis (P = 0.036).


Colostrum is suggested as an alternative prophylactic option for antibiotics against neonatal conjunctivitis. As colostrum is easily accessible without cost, potential hazards and side effects, public education about its topical favorable effects is worthwhile.


Antibiotic prophylaxis; colostrum; neonatal conjunctivitis; ophthalmia neonatorum

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