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Phys Biol. 2014 Aug;11(4):045004. doi: 10.1088/1478-3975/11/4/045004. Epub 2014 Jul 30.

Modeling and analysis of transport in the mammary glands.

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Department of Bioengineering, University of California Riverside, Riverside, CA 92521, USA.


The transport of three toxins moving from the blood stream into the ducts of the mammary glands is analyzed in this work. The model predictions are compared with experimental data from the literature. The utility of the model lies in its potential to improve our understanding of toxin transport as a pre-disposing factor to breast cancer. This work is based on a multi-layer transport model to analyze the toxins present in the breast milk. The breast milk in comparison with other sampling strategies allows us to understand the mass transport of toxins once inside the bloodstream of breastfeeding women. The multi-layer model presented describes the transport of caffeine, DDT and cimetidine. The analysis performed takes into account the unique transport mechanisms for each of the toxins. Our model predicts the movement of toxins and/or drugs within the mammary glands as well as their bioaccumulation in the tissues.

[Indexed for MEDLINE]

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