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Ulster Med J. 2014 May;83(2):86-8.

Hereditary Gigantism-the biblical giant Goliath and his brothers.

Author information

1
Regional Medical Genetics Centre, Queens University Belfast, Belfast City Hospital, Belfast, BT9 7AB, UK.
2
Regional Medical Genetics Centre, Queens University Belfast, Belfast City Hospital, Belfast, BT9 7AB, UK ; Centre for Cancer Research and molecular biology, Queens University Belfast, Belfast City Hospital, Belfast, BT9 7AB, UK.

Abstract

The biblical giant Goliath has an identifiable family tree suggestive of autosomal dominant inheritance. We suggest that he had a hereditary pituitary disorder possibly due to the AIP gene, causing early onset and familial acromegaly or gigantism. We comment on the evidence within the scriptures for his other relatives including a relative with six digits and speculate on possible causes of the six digits. Recognition of a hereditary pituitary disorder in the biblical Goliath and his family sheds additional information on his and other family members' battles with David and his relatives.

PMID:
25075136
PMCID:
PMC4113151
[Indexed for MEDLINE]
Free PMC Article

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