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Anticancer Res. 2014 Aug;34(8):4377-90.

Primary diffuse large B-cell lymphoma of the uterus: case report and review.

Author information

1
Unit of Obstetrics and Gynaecology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy dariomandato@virgilio.it.
2
Unit of Obstetrics and Gynaecology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
3
Unit of Haematology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
4
Unit of Pathology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
5
Unit of Obstetrics and Gynaecology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy University of Modena e Reggio Emilia, Reggio Emilia, Italy.

Abstract

BACKGROUND:

Primary diffuse large B-cell lymphoma of the cervix is a very rare disease, with non-specific clinical presentation. Its prognosis depends on accurate and timely diagnosis and therapy. Moreover, the management of this tumour has never been standardized.

CASE REPORT:

Herein we present a rare case of primary diffuse large B-cell lymphoma of the cervix misdiagnosed as cervical myoma. Our systematic review of the English literature identified 143 cases of primary diffuse large B-cell lymphoma of the uterus. Patients' characteristics and oncological, surgical, and safety data were recorded and analyzed.

CONCLUSION:

Although rare, primary diffuse large B-cell lymphoma of the cervix should never be ruled-out. Given its non-specific clinical symptoms, a multidisciplinary approach is required to perform a timely diagnosis and administer appropriate therapy. Immunochemotherapy (Rituximab + CHOP or CHOP-like regimen) with/without radiotherapy is the most common and most effective treatment; surgery should be avoided.

KEYWORDS:

Uterus; cervix; diagnosis; lymphoma; treatment; vaginal bleeding

PMID:
25075075
[Indexed for MEDLINE]
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