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Tumour Biol. 2014 Nov;35(11):10731-6. doi: 10.1007/s13277-014-2018-6. Epub 2014 Jul 30.

miR-24 promotes the proliferation and invasion of HCC cells by targeting SOX7.

Author information

1
Departments of Transplant Surgery, the Third Affiliated Hospital, Central South University, Hunan, China.

Abstract

Accumulating evidence shows that microRNAs (miRNAs) are involved in the development and progression of multiple tumors, including hepatocellular carcinoma (HCC). Recent studies have found that miR-24 acts as an oncogene in several tumors; however, the function of miR-24 in HCC remains unclear. In this study, we found that miR-24 was increased in HCC tissues and cell lines. Inhibition of miR-24 by inhibitor significantly suppressed HCC cells proliferation, migration, and invasion. Furthermore, the sex-determining region Y (SRY)-box 7 (SOX7), a putative tumor suppressor, was found to be a target of miR-24 in HCC cells. Forced expression of SOX7 substantially attenuated the oncogenic effects of miR-24. Those results strongly suggest that miR-24 plays important role in HCC development partially by targeting SOX7.

PMID:
25073511
DOI:
10.1007/s13277-014-2018-6
[Indexed for MEDLINE]

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