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Cell Microbiol. 2014 Oct;16(10):1473-83. doi: 10.1111/cmi.12334. Epub 2014 Aug 30.

Phosphoinositides and engulfment.

Author information

1
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, 48109-5620, USA.

Abstract

Cellular engulfment of particles, cells or solutes displaces large domains of plasma membrane into intracellular membranous vacuoles. This transfer of membrane is accompanied by major transitions of the phosphoinositide (PI) species that comprise the cytoplasmic face of membrane bilayers. Mapping of membrane PIs during engulfment reveals distinct patterns of protein and PI distributions associated with each stage of engulfment, which correspond with activities that regulate the actin cytoskeleton, membrane movements and vesicle secretion. Experimental manipulation of PI chemistry during engulfment indicates that PIs integrate organelle identity and orient signal transduction cascades within confined subdomains of membrane. These pathways are exploited by microbial pathogens to direct or redirect the engulfment process.

PMID:
25073505
PMCID:
PMC4341895
DOI:
10.1111/cmi.12334
[Indexed for MEDLINE]
Free PMC Article

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