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J Gen Virol. 2014 Nov;95(Pt 11):2372-6. doi: 10.1099/vir.0.068569-0. Epub 2014 Jul 29.

Origin of the European avian-like swine influenza viruses.

Author information

1
Institut für Virologie und Antivirale Therapie, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Hans-Knöll-Str. 2, D-07745 Jena, Germany.
2
Genomanalyse, Leibniz-Institut für Altersforschung - Fritz-Lipmann-Institut, Beutenbergstrasse 11, D-07745 Jena, Germany.
3
Institut für Medizinische Virologie, Justus-Liebig-Universität, Schubertstrasse 81, D-35392 Giessen, Germany.
4
Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Veterinärstrasse 2, D-85762 Oberschleissheim, Germany.
5
Virale Vakzinen, Geschäftsbereich Tiergesundheit, IDT Biologika GmbH, Am Pharmapark, D-06861 Dessau-Rosslau, Germany.
6
Institut für Virologie und Antivirale Therapie, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Hans-Knöll-Str. 2, D-07745 Jena, Germany roland.zell@med.uni-jena.de.

Abstract

The avian-like swine influenza viruses emerged in 1979 in Belgium and Germany. Thereafter, they spread through many European swine-producing countries, replaced the circulating classical swine H1N1 influenza viruses, and became endemic. Serological and subsequent molecular data indicated an avian source, but details remained obscure due to a lack of relevant avian influenza virus sequence data. Here, the origin of the European avian-like swine influenza viruses was analysed using a collection of 16 European swine H1N1 influenza viruses sampled in 1979-1981 in Germany, the Netherlands, Belgium, Italy and France, as well as several contemporaneous avian influenza viruses of various serotypes. The phylogenetic trees suggested a triple reassortant with a unique genotype constellation. Time-resolved maximum clade credibility trees indicated times to the most recent common ancestors of 34-46 years (before 2008) depending on the RNA segment and the method of tree inference.

PMID:
25073465
DOI:
10.1099/vir.0.068569-0
[Indexed for MEDLINE]

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