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Am J Psychiatry. 2014 Dec 1;171(12):1310-9. doi: 10.1176/appi.ajp.2014.13111499. Epub 2014 Oct 31.

Neural and cognitive correlates of the common and specific variance across externalizing problems in young adolescence.

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From the Department of Psychiatry and the Department of Psychoeducation, University of Montreal, and CHU Sainte-Justine Hospital, Montreal; the Department of Clinical and Cognitive Neuroscience and the Department of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; the Departments of Psychiatry and Psychology, University of Vermont, Burlington; the Institute of Psychiatry, King's College London; the Institute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin; University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Neurospin, Atomic Energy and Alternative Energies Commission, Paris; the Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin, Berlin; the School of Psychology and the School of Physics and Astronomy, University of Nottingham, Nottingham, U.K.; Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany; Institut National de la Santé et de la Recherche Médicale (INSERM) Unit 1000, Imaging and Psychiatry, SHFJ CEA, University of Paris South, Orsay, France; AP-HP Department of Adolescent Psychopathology and Medicine, Maison de Solenn, University Paris Descartes, Paris; Rotman Research Institute, University of Toronto, Toronto; Montreal Neurological Institute, McGill University, Montreal; Hospital for Sick Children, University of Toronto, Toronto; Behavioural and Clinical Neurosciences Institute, Department of Experimental Psychology, University of Cambridge, Cambridge, U.K.; the Department of Psychiatry and the Neuroimaging Center, Technische Universität Dresden, Germany; and MRC Social, Genetic, and Developmental Psychiatry (SGDP) Centre, London.


Longitudinal and family-based research suggests that conduct disorder, substance misuse, and ADHD involve both unique forms of dysfunction as well as more specific dysfunctions unique to each condition. Using direct measures of brain function, this study also found evidence in both unique and disorder-specific perturbations.

[Indexed for MEDLINE]

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