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Crit Rev Eukaryot Gene Expr. 2014;24(3):249-53.

Acupuncture, connective tissue, and peripheral sensory modulation.

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Department of Neurological Sciences, University of Vermont, Burlington, VT, Osher Center for Integrative Medicine, Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.


Although considerable controversy surrounds the legitimacy of acupuncture as a treatment, a growing literature on the physiological effects of acupuncture needling in animals and humans is providing new insights into basic cellular mechanisms including connective tissue mechanotransduction and purinergic signaling. This review summarizes these findings and proposes a model combining connective tissue plasticity and peripheral sensory modulation in response to the sustained stretching of tissue that results from acupuncture needle manipulation.

[Indexed for MEDLINE]

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