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J Pharm Sci. 2014 Oct;103(10):3120-6. doi: 10.1002/jps.24096. Epub 2014 Jul 28.

Evaluation of skin viability effect on ethosome and liposome-mediated psoralen delivery via cell uptake.

Author information

1
Department of Pharmaceutical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.

Abstract

This study investigated the effect of skin viability on its permeability to psoralen delivered by ethosomes, as compared with liposomes. With decreasing skin viability, the amount of liposome-delivered psoralen that penetrated through the skin increased, whereas skin deposition of psoralen from both ethosomes and liposomes reduced. Psoralen delivery to human-immortalized epidermal cells was more effective using liposomes, whereas delivery to human embryonic skin fibroblast cells was more effective when ethosomes were used. These findings agreed with those of in vivo studies showing that skin psoralen deposition from ethosomes and liposomes first increased and then plateaued overtime, which may indicate gradual saturation of intracellular drug delivery. It also suggested that the reduced deposition of ethosome- or liposome-delivered psoralen in skin with reduced viability may relate to reduced cellular uptake. This work indicated that the effects of skin viability should be taken into account when evaluating nanocarrier-mediated drug skin permeation.

KEYWORDS:

in vitro models; liposomes; nanotechnology; transcellular transport; transdermal

PMID:
25070929
DOI:
10.1002/jps.24096
[Indexed for MEDLINE]

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