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Trends Cardiovasc Med. 2014 Aug;24(6):256-62. doi: 10.1016/j.tcm.2014.05.010. Epub 2014 Jun 4.

Pin1: a molecular orchestrator in the heart.

Author information

1
Department of Biology, San Diego State University Heart Institute, San Diego State University, North Life Sciences, San Diego, CA.
2
Department of Biology, San Diego State University Heart Institute, San Diego State University, North Life Sciences, San Diego, CA. Electronic address: heartman4ever@icloud.com.

Abstract

Pin1 is an evolutionarily conserved peptidyl-prolyl isomerase that binds and changes the three-dimensional conformation of specific phospho-proteins. By regulating protein structure and folding, Pin1 affects the stability, interaction, and activity of a broad spectrum of target proteins, thus impacting upon diverse cellular processes. This review discusses the pivotal role Pin1 plays in regulating cardiac pathophysiology by functioning as a "molecular orchestrator" of a myriad of signal transduction pathways in the heart.

PMID:
25070718
PMCID:
PMC4150822
DOI:
10.1016/j.tcm.2014.05.010
[Indexed for MEDLINE]
Free PMC Article

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