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J Gerontol A Biol Sci Med Sci. 2015 Jul;70(7):791-9. doi: 10.1093/gerona/glu115. Epub 2014 Jul 28.

Fibroblasts From Longer-Lived Species of Primates, Rodents, Bats, Carnivores, and Birds Resist Protein Damage.

Author information

1
Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor.
2
Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor. millerr@umich.edu.

Abstract

Species differ greatly in their rates of aging. Among mammalian species life span ranges from 2 to over 60 years. Here, we test the hypothesis that skin-derived fibroblasts from long-lived species of animals differ from those of short-lived animals in their defenses against protein damage. In parallel studies of rodents, nonhuman primates, birds, and species from the Laurasiatheria superorder (bats, carnivores, shrews, and ungulates), we find associations between species longevity and resistance of proteins to oxidative stress after exposure to H(2)O(2) or paraquat. In addition, baseline levels of protein carbonyl appear to be higher in cells from shorter-lived mammals compared with longer-lived mammals. Thus, resistance to protein oxidation is associated with species maximal life span in independent clades of mammals, suggesting that this cellular property may be required for evolution of longevity. Evaluation of the properties of primary fibroblast cell lines can provide insights into the factors that regulate the pace of aging across species of mammals.

KEYWORDS:

Aging; Comparative biology; Key Words:; Oxidative stress.

PMID:
25070662
PMCID:
PMC4481684
DOI:
10.1093/gerona/glu115
[Indexed for MEDLINE]
Free PMC Article

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