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Ann Pharmacother. 2014 Nov;48(11):1406-14. doi: 10.1177/1060028014545038. Epub 2014 Jul 28.

Association of statins and risk of fractures in a military health system: a propensity score-matched analysis.

Author information

1
San Antonio Military Medical Center and the San Antonio Uniformed Services Health Consortium, Ft Sam Houston, TX, USA.
2
VA North Texas Health Care System, Dallas, TX, USA University of Texas Southwestern Medical Center, Dallas, TX, USA.
3
San Antonio Uniformed Services Health Education Consortium Brooke Army Medical Center, San Antonio, TX, USA.
4
The University of Texas at Austin, Austin, TX, USA The University of Texas Health Science Center, San Antonio, TX, USA.
5
VA North Texas Health Care System, Dallas, TX, USA University of Texas Southwestern Medical Center, Dallas, TX, USA Ishak.mansi@va.gov.

Abstract

BACKGROUND:

Contradictory evidence exists regarding statin use and risk of osteoporotic fractures.

OBJECTIVE:

The study objective was to examine the effect of statins on fracture risk in a Military Healthcare System (MHS) with similar access and standard of health care for its beneficiaries.

METHODS:

This is a retrospective study of patients enrolled in an MHS encompassing the period from October 1, 2003, to March 1, 2010. Statin users were defined as those receiving a statin for ≥90 days in Fiscal Year 2005, whereas nonusers were defined as individuals not receiving a statin throughout the study period. A propensity score-matched cohort of statin users and nonusers was created using 42 variables. The outcomes were identified using ICD-9-CM codes in the follow-up period (October 1, 2006, to March 1, 2010). In all, 4 outcomes were examined: all fractures, femoral neck fractures, upper-extremity fractures, and lower-extremity fractures.

RESULTS:

Of 46 249 patients, 6967 pairs of statin users and nonusers were matched. Statin users had a lower risk of femoral neck fracture in comparison to nonusers (odds ratio=0.58, 95% CI=0.36-0.94) but similar risk of all fractures, lower-extremity fractures, and upper-extremity fractures.

CONCLUSIONS:

In this cohort of patients managed in an MHS, statin use was associated with a lower risk of femoral neck fractures, but not all fractures, upper-extremity fractures, or lower-extremity fractures.

KEYWORDS:

fractures; hip fracture; observational studies; statin

PMID:
25070396
DOI:
10.1177/1060028014545038
[Indexed for MEDLINE]

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