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Methods Mol Biol. 2014;1181:167-76. doi: 10.1007/978-1-4939-1047-2_15.

Collagen-based engineered heart muscle.

Author information

1
Institute of Pharmacology, Heart Research Center Göttingen (HRCG), University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany.

Abstract

Cardiac muscle engineering has evolved over nearly 20 years from a scientific oddity to a mainstream technology with a wide range of applications. Of the many published methods it appears that hydrogels constitute the preferred scaffolds for myocardial tissue engineering and support of organotypic development. Here we describe a simple and highly robust protocol for the generation of engineered heart muscle using a collagen-based hydrogel method.

PMID:
25070336
DOI:
10.1007/978-1-4939-1047-2_15
[Indexed for MEDLINE]
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