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Pediatrics. 2014 Aug;134(2):315-24. doi: 10.1542/peds.2013-3990.

Longitudinal profiles of adaptive behavior in fragile X syndrome.

Author information

1
Marcus Autism Center, Children's Healthcare of Atlanta, Atlanta, Georgia;Emory University, School of Medicine, Atlanta, Georgia; Cheryl.klaiman@emory.edu.
2
Georgia Institute of Technology, School of Psychology, Atlanta, Georgia;
3
Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Brain Sciences, Stanford University, Palo Alto, California;
4
Carolina Institute for Developmental Disabilities, andDepartment of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina.
5
Center for Interdisciplinary Brain Sciences, Department of Psychiatry and Brain Sciences, Stanford University, Palo Alto, California;Departments of Radiology, andPediatrics, Stanford University, Palo Alto, California; and.

Abstract

OBJECTIVE:

To examine longitudinally the adaptive behavior patterns in fragile X syndrome.

METHOD:

Caregivers of 275 children and adolescents with fragile X syndrome and 225 typically developing children and adolescents (2-18 years) were interviewed with the Vineland Adaptive Behavior Scales every 2 to 4 years as part of a prospective longitudinal study.

RESULTS:

Standard scores of adaptive behavior in people with fragile X syndrome are marked by a significant decline over time in all domains for males and in communication for females. Socialization skills are a relative strength as compared with the other domains for males with fragile X syndrome. Females with fragile X syndrome did not show a discernible pattern of developmental strengths and weaknesses.

CONCLUSIONS:

This is the first large-scale longitudinal study to show that the acquisition of adaptive behavior slows as individuals with fragile X syndrome age. It is imperative to ensure that assessments of adaptive behavior skills are part of intervention programs focusing on childhood and adolescence in this condition.

KEYWORDS:

Vineland; adaptive behavior; adolescents; children; fragile X syndrome

PMID:
25070318
PMCID:
PMC4187230
DOI:
10.1542/peds.2013-3990
[Indexed for MEDLINE]
Free PMC Article

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