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Am J Gastroenterol. 2014 Aug;109(8):1159-79. doi: 10.1038/ajg.2014.186. Epub 2014 Jul 22.

Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-society Task Force on colorectal cancer.

Author information

1
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
2
Yale University School of Medicine, New Haven, Connecticut, USA.
3
Baylor University Medical Center, Dallas, Texas, USA.
4
Cleveland Clinic, Cleveland, Ohio, USA.
5
University of Utah, Salt Lake City, Utah, USA.
6
1] VA Puget Sound Health Care System, Seattle, Washington, USA [2] University of Washington, Seattle, Washington, USA.
7
Eastern Virginia Medical School, Norfolk, Virginia, USA.
8
Stanford University, Palo Alto, California, USA.
9
Kaiser Permanente Medical Center, Walnut Creek, California, USA.
10
Oregon Health and Science University, Portland, Oregon, USA.
11
1] White River Junction VA Medical Center, White River Junction, Vermont, USA [2] Geisel School of Medicine at Dartmouth, White River Junction, Vermont, USA.
12
1] Brigham and Women's Hospital, Boston, Massachusetts, USA [2] Dana Farber Cancer Institute, Boston, Massachusetts, USA [3] Harvard Medical School, Boston, Massachusetts, USA.
13
Indiana University School of Medicine, Indianapolis, Indiana, USA.

Abstract

The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: Figure 1 provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; Figure 2 illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; Figures 3,4,5,6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; Table 10 provides guidelines for screening at-risk and affected persons with Lynch syndrome; and Table 12 lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.

PMID:
25070057
DOI:
10.1038/ajg.2014.186
[Indexed for MEDLINE]
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