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J Interferon Cytokine Res. 2015 Jan;35(1):1-16. doi: 10.1089/jir.2014.0026. Epub 2014 Jul 28.

The role of cytokines in breast cancer development and progression.

Author information

1
1 Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México , México City, México.

Abstract

Cytokines are highly inducible, secretory proteins that mediate intercellular communication in the immune system. They are grouped into several protein families that are referred to as tumor necrosis factors, interleukins, interferons, and colony-stimulating factors. In recent years, it has become clear that some of these proteins as well as their receptors are produced in the organisms under physiological and pathological conditions. The exact initiation process of breast cancer is unknown, although several hypotheses have emerged. Inflammation has been proposed as an important player in tumor initiation, promotion, angiogenesis, and metastasis, all phenomena in which cytokines are prominent players. The data here suggest that cytokines play an important role in the regulation of both induction and protection in breast cancer. This knowledge could be fundamental for the proposal of new therapeutic approaches to particularly breast cancer and other cancer-related disorders.

PMID:
25068787
PMCID:
PMC4291218
DOI:
10.1089/jir.2014.0026
[Indexed for MEDLINE]
Free PMC Article

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