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Dermatol Surg. 2014 Aug;40(8):817-24. doi: 10.1111/dsu.0000000000000049.

Updated international clinical recommendations on scar management: part 1--evaluating the evidence.

Author information

1
*Gold Skin Care Center and Tennessee Clinical Research Center, Nashville, Tennessee; †Center for Clinical and Cosmetic Research, Aventura, Florida; ‡Department of Laser and Surgery, Istituto Dermatologico Europeo, Milano, Italy; §Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany; ‖Paces Plastic Surgery, Atlanta, Georgia; ¶Inkwell Medical Communications, Novelty, Ohio.

Abstract

BACKGROUND:

There is an ongoing need to standardize scar management by establishing safe and effective treatment options that can be applied in routine clinical practice.

OBJECTIVE:

To review available data on methods for preventing and treating cutaneous scarring.

MATERIALS AND METHODS:

Relevant scientific literature was identified through a comprehensive search of the MEDLINE database. Additional data and published studies were submitted for consideration by members of the International Advisory Panel on Scar Management.

RESULTS:

One of the most significant advances in scar management over the past 10 years has been the broader application of laser therapy, resulting in a shift in status from an emerging technology to the forefront of treatment. Accumulated clinical evidence also supports a greater role for 5-fluourouracil in the treatment of hypertrophic scars and keloids, particularly in combination with intralesional corticosteroids. Encouraging data have been reported for newer therapies, including bleomycin, onion extract-containing preparations, imiquimod, and mitomycin C, although methodologic limitations in available studies merit consideration. In general, clinical and aesthetic outcomes seem to be enhanced by a combination approach to treatment.

CONCLUSION:

Advances in therapeutic options and new study data necessitate a revision of algorithms for the prevention and management of cutaneous scarring.

PMID:
25068543
DOI:
10.1111/dsu.0000000000000049
[Indexed for MEDLINE]

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