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Vaccine. 2014 Sep 8;32(40):5221-7. doi: 10.1016/j.vaccine.2014.07.040. Epub 2014 Jul 25.

Enhanced immune responses of foot-and-mouth disease vaccine using new oil/gel adjuvant mixtures in pigs and goats.

Author information

1
Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city, Gyeonggido 430-757, Republic of Korea; Veterinary College, Chungnam National University, Yuseonggu, Daejeon 305-764, Republic of Korea.
2
Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city, Gyeonggido 430-757, Republic of Korea.
3
MJ Biologics, 1961 Premier Drive Suite 402, Mankato, MN 56001, USA.
4
Veterinary College, Chungnam National University, Yuseonggu, Daejeon 305-764, Republic of Korea.
5
Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city, Gyeonggido 430-757, Republic of Korea. Electronic address: parkjhvet@korea.kr.

Abstract

The immunity and protective capability produced by vaccines can vary remarkably according to the kinds of adjuvants being used. In the case of foot-and-mouth disease (FMD) vaccines in pigs, only oil-adjuvant vaccines have been used, and these tend to show lower immunity in pigs than in cattle. New adjuvants for these vaccines are therefore needed. We made different experimental FMD vaccines using new adjuvants (ISA 201, Carbigen, Emulsigen-D) and well-known adjuvants (ISA 206, aluminum hydroxide gel) and then conducted tests to compare the enhancement in pig immunity. More effective immune responses and protection against challenge were observed with the new adjuvants Emulsigen-D and ISA 201 compared to existing adjuvants. In the case of dairy goats, a mixture of Emulsigen-D and aluminum hydroxide gel produced rapid neutralizing antibody responses that were similar to results from tests conducted with pigs.

KEYWORDS:

Adjuvant; Foot-and-mouth disease; Immune response; Protection; Vaccine

PMID:
25066738
DOI:
10.1016/j.vaccine.2014.07.040
[Indexed for MEDLINE]
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