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An Pediatr (Barc). 2015 Apr;82(4):242-6. doi: 10.1016/j.anpedi.2014.05.023. Epub 2014 Jul 22.

[Viral respiratory tract infections in the Neonatal Intensive Care Unit].

[Article in Spanish]

Author information

1
Departamento de Neonatología y Pediatría, Hospital Severo Ochoa, Leganés, Madrid, España.
2
Departamento de Neonatología y Pediatría, Hospital Severo Ochoa, Leganés, Madrid, España. Electronic address: ccalvorey@ono.com.
3
Laboratorio de Virus Respiratorios y Gripe, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, España.

Abstract

INTRODUCTION:

Viral respiratory infections cause major morbidity and mortality in preterm infants. We have performed a prospective study in our neonatal intensive care unit (NICU) to determine the incidence of respiratory infections, their impact and the epidemiology and outcome in high risk neonates.

PATIENTS AND METHODS:

From September 2011 to May 2013 a prospective study was conducted in all preterm infants < 32 weeks gestational age and in all term newborns admitted to NICU for any pathology that are anticipated to have an income exceeding two weeks. A nasopharyngeal aspirate (NPA) was collected the first day of life and weekly until discharge for virologic study with polymerase chain reaction. When these babies presented respiratory symptoms a new NPA was collected in this moment. A clinical form was filled by the physician.

RESULTS:

A total of 60 infants were analyzed: 30 (50%) had a gestational age < 32 weeks and 36 (60%) weighing less than 1500 grams. We collected a total of 256 nasopharyngeal aspirate samples, 24 of them being positive (9.3%). These 24 positive samples corresponded to 13 infants in our cohort (21.6% of the patients). Of them, 9 were symptomatic and had 11 episodes of infection (2 patients had two different episodes with negative control between them). The most frequently identified virus was rhinovirus in (19) 79% of cases. The most frequent clinical data was the presence or increased of apneas (75%) and the needed of oxygenotherapy.

CONCLUSIONS:

HRV infections are prevalent in the NICU, and preterm infants have a high risk of infections with clinical relevance.

KEYWORDS:

Infecciones del tracto respiratorio; Preterm infants; Pretérmino; Respiratory syncytial virus; Respiratory tract infections; Rhinovirus; Rinovirus; Virus respiratorio sincitial

PMID:
25066594
DOI:
10.1016/j.anpedi.2014.05.023
[Indexed for MEDLINE]
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