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Asian Pac J Trop Med. 2014 Jun;7(6):492-5. doi: 10.1016/S1995-7645(14)60081-X.

Effect of acupuncture on inflammatory cytokines expression of spastic cerebral palsy rats.

Author information

1
Department of Neurology, Hebei Provincial People's Hospital, Canzhou 050051, China.
2
Third Hospital of Hebei Medical University, Department of Pediatric Orthopaedics, Cangzhou, Hebei, China.

Abstract

OBJECTIVE:

To To investigate the effect of acupuncture on the tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), nitric oxide synthase (NOS) content and muscular tension of spasticity cerebral palsy rat model.

METHODS:

The rats with spastic cerebral palsy were randomly divided into the control group, model group and acupuncture group. After successful modeling, the muscular tension and the content of TNF-α, IL-6, CRP, NOS were measured.

RESULTS:

The serum TNF-α, IL-6, CRP, NOS content were significantly decreased in the acupuncture group (P<0.05). The low and high shear viscosity of whole blood of the acupuncture group were significantly lower than the control group and the model group (P<0.05). The erythrocyte electrophoresis indexes in the acupuncture group were significantly lower than that in the model group and the control group (P<0.05). Acupuncture significantly reduced the muscular tension of spastic cerebral palsy rat and increased the active extent in the paralytic extremity (P<0.05), but it could not be restored to normal level. Compared with the control group, the difference had significant (P<0.05).

CONCLUSIONS:

Acupuncture treatment can inhibit the release of inflammatory cells after brain injury, then reduce immune injury, relieve muscle spasms and reduce muscular tension.

KEYWORDS:

Acupuncture; Inflammatory factors; Muscular tension; Spastic cerebral palsy

PMID:
25066401
DOI:
10.1016/S1995-7645(14)60081-X
[Indexed for MEDLINE]
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