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Asian Pac J Trop Med. 2014 Jun;7(6):492-5. doi: 10.1016/S1995-7645(14)60081-X.

Effect of acupuncture on inflammatory cytokines expression of spastic cerebral palsy rats.

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Department of Neurology, Hebei Provincial People's Hospital, Canzhou 050051, China.
Third Hospital of Hebei Medical University, Department of Pediatric Orthopaedics, Cangzhou, Hebei, China.



To To investigate the effect of acupuncture on the tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), nitric oxide synthase (NOS) content and muscular tension of spasticity cerebral palsy rat model.


The rats with spastic cerebral palsy were randomly divided into the control group, model group and acupuncture group. After successful modeling, the muscular tension and the content of TNF-α, IL-6, CRP, NOS were measured.


The serum TNF-α, IL-6, CRP, NOS content were significantly decreased in the acupuncture group (P<0.05). The low and high shear viscosity of whole blood of the acupuncture group were significantly lower than the control group and the model group (P<0.05). The erythrocyte electrophoresis indexes in the acupuncture group were significantly lower than that in the model group and the control group (P<0.05). Acupuncture significantly reduced the muscular tension of spastic cerebral palsy rat and increased the active extent in the paralytic extremity (P<0.05), but it could not be restored to normal level. Compared with the control group, the difference had significant (P<0.05).


Acupuncture treatment can inhibit the release of inflammatory cells after brain injury, then reduce immune injury, relieve muscle spasms and reduce muscular tension.


Acupuncture; Inflammatory factors; Muscular tension; Spastic cerebral palsy

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