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Microbes Infect. 2014 Aug;16(8):690-4. doi: 10.1016/j.micinf.2014.07.003. Epub 2014 Jul 25.

Evidence of a conserved role for Chlamydia HtrA in the replication phase of the chlamydial developmental cycle.

Author information

1
Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia.
2
Faculty of Science, Health, Education, and Engineering, University of the Sunshine Coast, Maroochydore DC, QLD 4558, Australia.
3
Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD 4059, Australia. Electronic address: w.huston@qut.edu.au.

Abstract

Identification of the HtrA inhibitor JO146 previously enabled us to demonstrate an essential function for HtrA during the mid-replicative phase of the Chlamydia trachomatis developmental cycle. Here we extend our investigations to other members of the Chlamydia genus. C. trachomatis isolates with distinct replicative phase growth kinetics showed significant loss of viable infectious progeny after HtrA was inhibited during the replicative phase. Mid-replicative phase addition of JO146 was also significantly detrimental to Chlamydia pecorum, Chlamydia suis and Chlamydia cavie. These data combined indicate that HtrA has a conserved critical role during the replicative phase of the chlamydial developmental cycle.

KEYWORDS:

Chlamydia; HtrA; Inhibitor; Protease

PMID:
25066238
DOI:
10.1016/j.micinf.2014.07.003
[Indexed for MEDLINE]

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