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Microbiologyopen. 2014 Oct;3(5):702-10. doi: 10.1002/mbo3.200. Epub 2014 Jul 25.

Ultrastructure and complex polar architecture of the human pathogen Campylobacter jejuni.

Author information

1
Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E. California Blvd., Pasadena, California, 91125.

Abstract

Campylobacter jejuni is one of the most successful food-borne human pathogens. Here we use electron cryotomography to explore the ultrastructure of C. jejuni cells in logarithmically growing cultures. This provides the first look at this pathogen in a near-native state at macromolecular resolution (~5 nm). We find a surprisingly complex polar architecture that includes ribosome exclusion zones, polyphosphate storage granules, extensive collar-shaped chemoreceptor arrays, and elaborate flagellar motors.

KEYWORDS:

Acidocalcisomes; Campylobacterales; chemoreceptors; cryo-EM; cryoelectron tomography; food poisoning; polyphosphate storage granules

PMID:
25065852
PMCID:
PMC4234261
DOI:
10.1002/mbo3.200
[Indexed for MEDLINE]
Free PMC Article
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