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Matrix Biol. 2014 Jul;37:1-14. doi: 10.1016/j.matbio.2014.07.005. Epub 2014 Jul 24.

Revisiting the matricellular concept.

Author information

1
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294-0019, United States. Electronic address: murphy@uab.edu.

Abstract

The concept of a matricellular protein was first proposed by Paul Bornstein in the mid-1990s to account for the non-lethal phenotypes of mice with inactivated genes encoding thrombospondin-1, tenascin-C, or SPARC. It was also recognized that these extracellular matrix proteins were primarily counter or de-adhesive. This review reappraises the matricellular concept after nearly two decades of continuous investigation. The expanded matricellular family as well as the diverse and often unexpected functions, cellular location, and interacting partners/receptors of matricellular proteins are considered. Development of therapeutic strategies that target matricellular proteins are discussed in the context of pathology and regenerative medicine.

KEYWORDS:

CCN; Cell adhesion; Extracellular matrix; Fibulin; Hevin; Matricellular; Osteopontin; Periostin; R-spondin; Regenerative medicine; SPARC; Tenascins; Thrombospondins

PMID:
25064829
PMCID:
PMC4379989
DOI:
10.1016/j.matbio.2014.07.005
[Indexed for MEDLINE]
Free PMC Article

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