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Nat Immunol. 2014 Sep;15(9):856-65. doi: 10.1038/ni.2947. Epub 2014 Jul 27.

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells.

Author information

1
Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
2
1] Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA. [2].

Abstract

Understanding the developmental mechanisms of follicular helper T cells (TFH cells) in humans is relevant to the clinic. However, the factors that drive the differentiation of human CD4+ helper T cells into TFH cells remain largely undefined. Here we found that transforming growth factor-β (TGF-β) provided critical additional signals for the transcription factors STAT3 and STAT4 to promote initial TFH differentiation in humans. This mechanism did not appear to be shared by mouse helper T cells. Developing human TFH cells that expressed the transcriptional repressor Bcl-6 also expressed RORγt, a transcription factor typically expressed by the TH17 subset of helper T cells. Our study documents a mechanism by which TFH cells and TH17 cells emerge together in inflammatory environments in humans, as is often observed in many human autoimmune diseases.

PMID:
25064073
PMCID:
PMC4183221
DOI:
10.1038/ni.2947
[Indexed for MEDLINE]
Free PMC Article

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