Format

Send to

Choose Destination
Curr Opin Pharmacol. 2014 Dec;19:46-53. doi: 10.1016/j.coph.2014.07.006. Epub 2014 Jul 24.

RNA-binding proteins and microRNAs in gastrointestinal epithelial homeostasis and diseases.

Author information

1
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, USA; Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA.
2
Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, USA; Department of Pathology, University of Maryland School of Medicine, USA; Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA. Electronic address: jwang@smail.umaryland.edu.

Abstract

The epithelium of gastrointestinal (GI) mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through strict regulation of cell proliferation and apoptosis. Epithelial cells originate from a small number of pluripotent stem cells, which divide to either renew themselves or become committed crypt cells. RNA-binding proteins (RBPs) and microRNAs (miRNAs) regulate gene expression at the posttranscriptional level and are recently shown to modulate GI mucosal growth and repair after injury. Here we highlight the roles of RBPs HuR, CUG-binding protein 1, AU-binding factor 1, and several GI epithelial-specific miRNAs in gut mucosal homeostasis and diseases and also further analyze the mechanisms through which RBPs and miRNAs modulate the stability and translation of target mRNAs.

PMID:
25063919
PMCID:
PMC4254056
DOI:
10.1016/j.coph.2014.07.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center