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J Pediatr. 2014 Oct;165(4):744-9. doi: 10.1016/j.jpeds.2014.06.039. Epub 2014 Jul 22.

Association of urinary phenols with increased body weight measures and obesity in children and adolescents.

Author information

1
Division of Toxicology and Human Health Sciences, Centers for Disease Control and Prevention, Agency for Toxic Substances and Disease Registry, Atlanta, GA.
2
Division of Toxicology and Human Health Sciences, Centers for Disease Control and Prevention, Agency for Toxic Substances and Disease Registry, Atlanta, GA. Electronic address: fes6@cdc.gov.

Abstract

OBJECTIVE:

To examine the association of urinary levels of the environmental phenol pesticides 2,5-dichlorophenol, 2,4-dichlorophenol, and triclosan with body weight outcomes in children and adolescent participants in the National Health and Nutrition Examination Survey 2007-2010.

STUDY DESIGN:

We performed multivariate linear and multinomial logistic regressions to analyze the association of body mass index (BMI) z-score, waist circumference (WC), and obesity with urinary pesticide concentration in children and adolescents.

RESULTS:

After adjustment for covariates, we found a statistically significant positive association (P < .05) between both 2,5-dichlorophenol and 2,4-dichlorophenol with BMI z-score, WC, and obesity in children and adolescents. After stratification by age, the significant associations remained only in adolescents (ages 12-19). No associations were found between triclosan and any of the body weight outcomes.

CONCLUSIONS:

We found an association between dichlorophenols and increased body weight measures (BMI z-score, WC, and obesity) in adolescents. However, further studies, such as a longitudinal study, are needed to confirm and elucidate on our findings.

PMID:
25063718
DOI:
10.1016/j.jpeds.2014.06.039
[Indexed for MEDLINE]

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