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J Am Soc Nephrol. 2015 Jan;26(1):183-91. doi: 10.1681/ASN.2013111236. Epub 2014 Jul 25.

Vascular access choice in incident hemodialysis patients: a decision analysis.

Author information

1
Department of Medicine, Division of Nephrology and.
2
Department of Medicine, Division of Nephrology, Toronto General Hospital, Toronto, Ontario, Canada;
3
Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, Massachusetts;
4
Institute of Clinical Epidemiology and Biometry and Department of Medicine I, Division of Nephrology, University of Würzburg, Würzburg, Germany; and.
5
Department of Medicine, Division of Nephrology, Seven Oaks General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada.
6
Department of Medicine, Division of Nephrology and dweiner@tuftsmedicalcenter.org.

Abstract

Hemodialysis vascular access recommendations promote arteriovenous (AV) fistulas first; however, it may not be the best approach for all hemodialysis patients, because likelihood of successful fistula placement, procedure-related and subsequent costs, and patient survival modify the optimal access choice. We performed a decision analysis evaluating AV fistula, AV graft, and central venous catheter (CVC) strategies for patients initiating hemodialysis with a CVC, a scenario occurring in over 70% of United States dialysis patients. A decision tree model was constructed to reflect progression from hemodialysis initiation. Patients were classified into one of three vascular access choices: maintain CVC, attempt fistula, or attempt graft. We explicitly modeled probabilities of primary and secondary patency for each access type, with success modified by age, sex, and diabetes. Access-specific mortality was incorporated using preexisting cohort data, including terms for age, sex, and diabetes. Costs were ascertained from the 2010 USRDS report and Medicare for procedure costs. An AV fistula attempt strategy was found to be superior to AV grafts and CVCs in regard to mortality and cost for the majority of patient characteristic combinations, especially younger men without diabetes. Women with diabetes and elderly men with diabetes had similar outcomes, regardless of access type. Overall, the advantages of an AV fistula attempt strategy lessened considerably among older patients, particularly women with diabetes, reflecting the effect of lower AV fistula success rates and lower life expectancy. These results suggest that vascular access-related outcomes may be optimized by considering individual patient characteristics.

KEYWORDS:

dialysis access; hemodialysis; survival

Comment in

PMID:
25063436
PMCID:
PMC4279737
DOI:
10.1681/ASN.2013111236
[Indexed for MEDLINE]
Free PMC Article

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