Decreased proliferation ability and differentiation potential of mesenchymal stem cells of osteoporosis rat

Asian Pac J Trop Med. 2014 May;7(5):358-63. doi: 10.1016/S1995-7645(14)60055-9.

Abstract

Objective: To explore decreased proliferation ability and differentiation potential of mesenchymal stem cells (MSCs) of osteoporosis rat.

Methods: MSCs were obtained from osteoporosis rat, and proliferation potency and impaired osteogenic differentiation potential were determined.

Results: The result showed a significant downregulation of MSCs pluripotency related gene (Oct 4) and osteogenic genes (BSP, OCN) expression in OVX MSCs compared with Sham MSCs (P<0.05).

Conclusions: These data suggest that MSCs are aging in osteoporosis body, and autologous OVX MSCs transplantation is not appropriate to treat osteoporosis if necessary. There will be a possibility in establishing a new clinical application of MSCs autologous transplantation to treat osteoporosis, if OVX MSCs have stronger proliferation and differentiation.

Keywords: Differentiation; Mesenchymal stem cells; Osteoporosis; Proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Differentiation / physiology*
  • Cell Proliferation / physiology*
  • Disease Models, Animal
  • Female
  • Mesenchymal Stem Cells / cytology
  • Mesenchymal Stem Cells / physiology*
  • Osteoporosis / physiopathology*
  • Ovariectomy
  • Rats
  • Rats, Sprague-Dawley