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Methods Mol Biol. 2014;1185:279-84. doi: 10.1007/978-1-4939-1133-2_19.

Homing and migration assays of hematopoietic stem/progenitor cells.

Author information

1
Stowers Institute for Medical Research, Kansas City, MO, USA.

Abstract

Hematopoietic stem and progenitor cells (HSPCs) reside mainly in bone marrow; however, under homeostatic and stressed conditions, HSPCs dynamically change their location-either egressing from bone marrow and getting into circulation, a process of mobilization; or coming back to the bone marrow, the homing process. How to analyze these two processes will be critical for understanding the behavior of HSPCs. Here we provide an experimental protocol to monitor and analyze homing and migration of HSPCs.

PMID:
25062636
DOI:
10.1007/978-1-4939-1133-2_19
[Indexed for MEDLINE]

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