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Genet Mol Res. 2014 Jul 2;13(3):4756-65. doi: 10.4238/2014.July.2.5.

Genetic diversity of HLA-DRB1 alleles in the Tujia population of Wufeng, Hubei Province, China.

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Institute of Virology, Medical School of Wuhan University, Wuhan, Hubei, China.
The Clinical Laboratory, Wuhan Hospital, Wuhan, China.
Medical School of Hubei University of Science and Technology, Hubei, China.
Wuhan Nursing Home Hot Spring Rehabilitation Sanitarium Area, Xianning, Hubei, China.
Department of Medicine and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Institute of Virology, Medical School of Wuhan University, Wuhan, Hubei, China


We established a genetic database by investigating human leukocyte antigen (HLA)-DRB1 allelic frequencies in a disease-association study in the Tujia population in Wufang, Hubei, China. The allele frequencies of the HLA-DRB1 locus in 262 healthy, unrelated Tujia individuals living in the Wufeng region of the Hubei Province were analyzed using the Luminex HLA sequence-specific oligonucleotide method with a WAKFlow HLA typing kit. A total of 13 alleles were detected at the HLA-DRB1 locus. HLA-DRB1*09 was the most common allele (22.52%), followed by DRB1*08 and DRB1*15 (11.07%), and DRB1*12 and DRB1*04 (10.69%). These data were compared with the results obtained for 10 other ethnic groups living in other regions as well as to Han groups using neighbor-joining dendrograms and principal component analysis. The results showed that the Tujia population has a close genetic relationship with the Middle Han population at the HLA-DRB1 locus. This information will be useful for HLA-DRB1-linked disease-association studies.

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