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Sleep. 2014 Jul 1;37(7):1171-8. doi: 10.5665/sleep.3832.

Sleep duration and age-related changes in brain structure and cognitive performance.

Author information

1
Center for Cognitive Neuroscience, Neuroscience and Behavioral Disorders Program, Duke-NUS Graduate Medical School, Singapore.

Abstract

STUDY OBJECTIVES:

To investigate the contribution of sleep duration and quality to age-related changes in brain structure and cognitive performance in relatively healthy older adults.

DESIGN:

Community-based longitudinal brain and cognitive aging study using a convenience sample.

SETTING:

Participants were studied in a research laboratory.

PARTICIPANTS:

Relatively healthy adults aged 55 y and older at study commencement.

INTERVENTIONS:

N/A.

MEASUREMENTS AND RESULTS:

Participants underwent magnetic resonance imaging and neuropsychological assessment every 2 y. Subjective assessments of sleep duration and quality and blood samples were obtained. Each hour of reduced sleep duration at baseline augmented the annual expansion rate of the ventricles by 0.59% (P = 0.007) and the annual decline rate in global cognitive performance by 0.67% (P = 0.050) in the subsequent 2 y after controlling for the effects of age, sex, education, and body mass index. In contrast, global sleep quality at baseline did not modulate either brain or cognitive aging. High-sensitivity C-reactive protein, a marker of systemic inflammation, showed no correlation with baseline sleep duration, brain structure, or cognitive performance.

CONCLUSIONS:

In healthy older adults, short sleep duration is associated with greater age-related brain atrophy and cognitive decline. These associations are not associated with elevated inflammatory responses among short sleepers.

CITATION:

Lo JC, Loh KK, Zheng H, Sim SK, Chee MW. Sleep duration and age-related changes in brain structure and cognitive performance.

KEYWORDS:

aging; brain structure; cognitive performance; sleep duration; sleep quality

PMID:
25061245
PMCID:
PMC4098802
DOI:
10.5665/sleep.3832
[Indexed for MEDLINE]
Free PMC Article

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