Format

Send to

Choose Destination
Ultrason Imaging. 2015 Jan;37(1):22-41. doi: 10.1177/0161734614542177. Epub 2014 Jul 23.

B-mode and acoustic radiation force impulse (ARFI) imaging of prostate zonal anatomy: comparison with 3T T2-weighted MR imaging.

Author information

1
Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, USA mark.palmeri@duke.edu.
2
Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, USA.
3
Duke University School of Medicine, Durham, NC, USA.
4
Department of Radiology, Duke University Medical Center, Durham, NC, USA.
5
Department of Surgery (Urology), Duke University Medical Center, Durham, NC, USA.
6
Department of Pathology, Duke University Medical Center, Durham, NC, USA.

Abstract

Prostate cancer (PCa) is the most common non-cutaneous malignancy among men in the United States and the second leading cause of cancer-related death. Multi-parametric magnetic resonance imaging (mpMRI) has gained recent popularity to characterize PCa. Acoustic Radiation Force Impulse (ARFI) imaging has the potential to aid PCa diagnosis and management by using tissue stiffness to evaluate prostate zonal anatomy and lesions. MR and B-mode/ARFI in vivo imaging datasets were compared with one another and with gross pathology measurements made immediately after radical prostatectomy. Images were manually segmented in 3D Slicer to delineate the central gland (CG) and prostate capsule, and 3D models were rendered to evaluate zonal anatomy dimensions and volumes. Both imaging modalities showed good correlation between estimated organ volume and gross pathologic weights. Ultrasound and MR total prostate volumes were well correlated (R(2) = 0.77), but B-mode images yielded prostate volumes that were larger (16.82% ± 22.45%) than MR images, due to overestimation of the lateral dimension (18.4% ± 13.9%), with less significant differences in the other dimensions (7.4% ± 17.6%, anterior-to-posterior, and -10.8% ± 13.9%, apex-to-base). ARFI and MR CG volumes were also well correlated (R(2) = 0.85). CG volume differences were attributed to ARFI underestimation of the apex-to-base axis (-28.8% ± 9.4%) and ARFI overestimation of the lateral dimension (21.5% ± 14.3%). B-mode/ARFI imaging yielded prostate volumes and dimensions that were well correlated with MR T2-weighted image (T2WI) estimates, with biases in the lateral dimension due to poor contrast caused by extraprostatic fat. B-mode combined with ARFI imaging is a promising low-cost, portable, real-time modality that can complement mpMRI for PCa diagnosis, treatment planning, and management.

KEYWORDS:

ARFI imaging; MR imaging; elasticity; image segmentation; prostate; tissue modeling; visualization

PMID:
25060914
PMCID:
PMC4423560
DOI:
10.1177/0161734614542177
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center